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Polymyxin B Sulphate EP 10,000 units per ml

Neomycin Sulphate EP 3,400 units per ml

Hydrocortisone EP 1.0% w/v

Hydrocortisone belongs to a group of medicines, known as corticosteroids, that are used for reducing inflammation. Inflammation occurs as a result of allergy or irritation and is caused by the release of substances that are important in the immune system. These substances cause blood vessels to widen, resulting in the affected area becoming red, swollen, itchy and painful. Corticosteroids work by acting within cells to decrease the release of these substances in a particular area, thereby reducing swelling, redness and itch.

Neomycin belongs to a group of antibiotics called aminoglycosides. These antibiotics have the ability to kill a wide variety of bacteria. Neomycin binds to components in the bacterial cell, which results in the production of abnormal proteins. These proteins are normally necessary for the bacteria's survival, therefore the production of abnormal proteins is ultimately fatal to the bacteria.

Polymixin B belongs to a class of antibiotics called polymyxins. They destroy bacteria by interfering with the function of part of the bacteria's cell wall. This results in leaking of the contents of the cell leading the to death of the bacteria.

These medicines are used in combination in the treatment of external ear infections, caused or complicated by bacterial infection (otitis externa).